Citation: Hai Bo Wang, Ping An Wang, Quan Jun Wang, Xiao Li Sun, Lin Lin Jing. A convenient microwave-assisted synthesis of cinchona alkaloid-derived ligands[J]. Chinese Chemical Letters, ;2008, 19(12): 1440-1444. doi: 10.1016/j.cclet.2008.09.049 shu

A convenient microwave-assisted synthesis of cinchona alkaloid-derived ligands

Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China

Received Date: 27 June 2008

Fund Project: We would like to thank the National Natural Science Foundation of China (No. 20672141) for financial support of this work.

An efficient synthesis of cinchona alkaloid-derived ligands based on solvent-free microwave-assisted reaction was described. The coupling of 1,4-dichlorophthalazine or 3,6-dichloropyridazine with quinine, cinchonine or cinchonidine provide bis- or mono-cinchona alkaloid-derived ligands in moderate to good yields (52-89%) within 15 rain under optimum microwave conditions.
- Cinchona alkaloids,
- Solvent-free microwave synthesis,
- AD reaction
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