Citation: Hua Wang, Qi Dong You, Zhi Yu Li, Yi Quan Zou. Design, synthesis and antitumor activity of 3-substituted quinolone derivatives (Ⅰ)[J]. Chinese Chemical Letters, ;2008, 19(12): 1395-1397. doi: 10.1016/j.cclet.2008.09.034 shu

Design, synthesis and antitumor activity of 3-substituted quinolone derivatives (Ⅰ)

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 12 May 2008

Fund Project: The work was supported by National Natural Science Foundation of China (No. 30271543).

A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Be17402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor cells are comparable to that of topotecan, one of topoisomerase I inhibitors.
- Quinolone derivatives,
- Synthesis,
- Anfitumor
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