Citation: Chang Feng Hu, Chuan Jun Zhu, Yan Feng Gao, Xuan Shao, Rui Wang, Yu Xin Cui. Characteristic fragmentation behavior of the analogs of endomorphin-2 with phenylglycine in position 3 or 4 by ESI-FT tandem mass spectrometry[J]. Chinese Chemical Letters, ;2008, 19(12): 1479-1482. doi: 10.1016/j.cclet.2008.09.023 shu

Characteristic fragmentation behavior of the analogs of endomorphin-2 with phenylglycine in position 3 or 4 by ESI-FT tandem mass spectrometry

a State Key Laboratory of Natural and Biomimetic Drugs(Peking University), Beijing 100083, China;
b School of Life Science, Lanzhou University, Lanzhou 730000, China

Received Date: 2 June 2008

A series of analogs of endomorphin-2(EM-2) with phenylglycine (Phg) in position 3 or 4 were synthesized. In electrospray ionization Fourier transform ion cyclotron resonance (ESI-FT-ICR) MS/MS spectra of these compounds, some b, y, a, and internal ions were observed and slight mass differences between the calculated and observed results are obtained. Their sequences were derived successfully. However, the MS/MS patterns of these analogs with ^DPhg and ^Lphg were very similar. It is hard to distinguish them by MS/MS spectra. Moreover, if the third position was substituted by phenylglyeine (L or D), a rearrangement could occur in MS/MS experiment to lose proline residue.
- Endomorphin-2,
- Opioid peptide analogs,
- Phenylglycine,
- ESI-FT MS
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