Citation: Di Zao Li, Xian Dao Pan, Hong Yan Liu, Song Wu. Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins[J]. Chinese Chemical Letters, ;2008, 19(10): 1202-1205. doi: 10.1016/j.cclet.2008.07.022 shu

Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received Date: 25 April 2008

Fund Project: The authors wish to thank Feiyun company (Huangshi, Hubei, China) and Hengrui Medicine Co., Ltd. (Lianyungang, Jiangsu, China) for their kindness in supplying camptothecin, 10-hydroxycamptothecin and topotecan, respectively.

A series of 5-C-alkylating camptothecins have been synthesized by one-step method.and their in vitro antitumor activity was evaluated against six human cancer cell lines.The results showed that all 5-C-alkylatcs of camptothecins possessed poor cytotoxicity on six human cancer cell lines.
- Camptothecin,
- Synthesis,
- 5-C-Alkylate,
- Antitumor aetivity
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