Citation: Bin Wu, Li Zhou, Hui Hui Cai. Synthesis and neuroprotective properties of novel cinnamide dertvatives[J]. Chinese Chemical Letters, ;2008, 19(10): 1163-1166. doi: 10.1016/j.cclet.2008.06.052 shu

Synthesis and neuroprotective properties of novel cinnamide dertvatives

School of Pharmacy, Nanjing Medical University, Nanjing 210029, China

Received Date: 27 March 2008

Fund Project: This work is financially supported by the Natural Science Foundation of Education Department of Jiangsu Province (No. 05KJB350084).

A new series of compounds (E)-1-(4-(bis-arylmethyl)piperazin-l-y1)-3-arylprop-2-en-1-one(1a-r),have been synthesized and their structures were confirmed by ESI-MS and ¹H NMR.The preliminary pharmacological screening showed that some of these compounds had similar neuroprotective effects with Edaravone.
- Cinnamide derivatives,
- Synthesis,
- Neuroprotective,
- Fdaravone
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