Citation: Nasser Montazeri, Kurosh Rad-Moghadam. An expeditious and one-pot synthesis of unsymmetrical 2,5-disubstituted-1,3,4-oxadiazoles under microwave irradiation and solvent-free conditions[J]. Chinese Chemical Letters, ;2008, 19(10): 1143-1146. doi: 10.1016/j.cclet.2008.06.050 shu

An expeditious and one-pot synthesis of unsymmetrical 2,5-disubstituted-1,3,4-oxadiazoles under microwave irradiation and solvent-free conditions

Nasser Montazeri ^a, ,
Kurosh Rad-Moghadam ^b

Chemistry Department, Azad University of Tonekabon, Tonekabon 46841-61167, Iean;
b Chemistry Department, University of Guilan, Rasht, P. O. Box 41335-1914, Iran

Received Date: 28 January 2008

A one-pot synthesis of some unsymmetrical 2,5-disubstituted-1,3,4-oxadiazoles via cyclocondensation of benzoylhydrazines with orthoesters under solvent-free and microwave conditions are described here.The reaction is efficiently catalyzed by silicasupported sulfuric acid as it provided the title compounds in high yields and relatively short times.The catalyst is reusable and can be applied several times without considerable decrease in the yields and rates of the reactions.
- 2,5-Disubstituted-1,3,4-oxadiazoles,
- Silica-supported sulfuric acid,
- Solvent-free,
- Microwave,
- Orthoester
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