Citation: Wei Zhang, Tian Tian Sun, Duo Mei, Jun Fei Wang, Ying Xia Li. Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins[J]. Chinese Chemical Letters, ;2008, 19(9): 1068-1070. doi: 10.1016/j.cclet.2008.06.027 shu

Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

Key laboratory of Marine Drugs, The Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, China

Received Date: 27 March 2008

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 30572245), Hi- Tech Research and Development Program of China (863 program, No. 2006AA09Z409), and The Excellent Young Scientists Foundation of Shandong Province (No. 2006BS02013).

The protected 2S,4R-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and SchÖllkopf amino acid synthesis as key steps.
- Synthesis,
- Amino acid,
- SehÖllkopf methodology,
- Culicinins
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