Citation: Qing Han Li, Zhi Gang Zhao. Microwave-assisted synthesis of new N⁴-[bi-(4-fluorophenyl)-methyl]-piperazine thiosemicarbazones under solvent-free conditions[J]. Chinese Chemical Letters, ;2008, 19(9): 1035-1038. doi: 10.1016/j.cclet.2008.06.018 shu

Microwave-assisted synthesis of new N⁴-[bi-(4-fluorophenyl)-methyl]-piperazine thiosemicarbazones under solvent-free conditions

College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China

Received Date: 10 March 2008

Fund Project: The authors are grateful for financial support for this work from Natural Foundation of Southwest University for Nationalities (No. 234688).

Six new N⁴-[bi-(4-fluorophenyl)-methyl]-piperazine thiosemicarbazones 3a-f have been prepared starting from[bi-(4-fluor-ophenyl)-methyl]-piperazine in solvent-free condition under microwave irradiation with excellent yields. Their structures have been determined by elemental analysis, IR, MS and ¹H NMR data.
- bi-(4-Fluorophenyl)-methyl]-piperazine,
- Thiosemiearbazones,
- Microwave irradiation,
- Solvent-free,
- Organic synthese
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