Citation: Yang Liu, Jun Liang, Xiu Hong Liu, Ji Cai Fan, Zhi Cai Shang. Polyethylene glycol (PEG) as a benign solvent for Knoevenagel condensation[J]. Chinese Chemical Letters, ;2008, 19(9): 1043-1046. doi: 10.1016/j.cclet.2008.06.016 shu

Polyethylene glycol (PEG) as a benign solvent for Knoevenagel condensation

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Received Date: 19 March 2008

The Knoevenagel condensation of aromatic aldehydes with active methylene compound proceeded efficiently in polyethylene glycol at room temperature with L-proline as catalyst. The yield is high and the products had E-isomer dominantly. Polyethylene glycol containing L-proline could be recycled and reused for several times without noticeably decreasing in productivity.
- Polyethylene glycol,
- L-Proline,
- Knoevenagel condensation
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