Citation: Die Cheng, Deng Ke Liu, Mo Liu, Ying Liu, Wei Ren Xu, Chang Xiao Liu. Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine[J]. Chinese Chemical Letters, ;2008, 19(9): 1075-1079. doi: 10.1016/j.cclet.2008.06.008 shu

Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine

Die Cheng ^a,b,c, ,
Deng Ke Liu ^b ,
Mo Liu ^b ,
Ying Liu ^b ,
Wei Ren Xu ^b ,
Chang Xiao Liu ^c

a Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China;
b Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, People's Republic of China;
c State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, People's Republic of China

Received Date: 15 April 2008

A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno[3,2-c] pyridine were synthesized and strucmrally characterized by ¹H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design.
- Thienopyfidines,
- Anti-platelet aggregation activities,
- P2Y₁₂ receptors,
- 3D-QSAR
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