Citation: Guo Wei Yin, Yi Ming Li, Wei Wei, Shan Hao Jiang, Da Yuan Zhu, Wei Hong Du. Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate[J]. Chinese Chemical Letters, ;2008, 19(6): 747-751. doi: 10.1016/j.cclet.2008.04.013 shu

Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate

a Department of Chemistry, Renmin University of China, 59 Zhong Guan Cun Street, Beijing 100872, China;
b School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203,China;
c State Key Laboratory for Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

Received Date: 22 November 2007

Fund Project: The authors are grateful for supports by the National Natural Science Foundation of China (No. 90409015 and 20473013).

In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (AChE) inhibition, two main ingredients, salvianolic acid B (1) and rosmarinic acid (2), which were isolated from S. miltiorhiza water extract, were investigated in vitro byNMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have AChE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.
- AChE inhibitors,
- Salvianolic acid B,
- Rosmarinic acid,
- NMR relaxation rate
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