Citation: Li Jun Li, Qi Feng Chen, Hao Cheng, Lai Bo Yu, Jian Ling Wu. Determination of levodopa in pharmaceutical preparations by irreversible biamperometry[J]. Chinese Chemical Letters, ;2008, 19(6): 703-706. doi: 10.1016/j.cclet.2008.04.001 shu

Determination of levodopa in pharmaceutical preparations by irreversible biamperometry

a Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou 545006, China;
b College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004,China

Received Date: 4 December 2007

Fund Project: Guangxi Science Fund (No. 0640029) and Master Fund of Guangxi University of Technology.Thanks for the financial support of National Natural Science Foundation of China (No. 20665001)

Based on the electrocatalytic oxidation of levodopa at gold electrode and the reduction of permanganate at platinum electrode, a novel flow injection irreversible biamperometric method is developed for the determination of levodopa under the potential difference of 0 V imposed between two electrodes. In H₂SO₄ solution, the linear relationships between currents and the concentrations of levodopa are obtained in the range from 0.04mg/L to 20mg/L with the detection limit of 0.012mg/L. The proposed method is applied to the determination of levodopa in pharmaceutical preparations.
- Flow injection,
- Levodopa,
- Irreversible biamperometry,
- Gold electrode,
- Platinum electrode
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