Citation: Shahnaz Rostamizadeh, Somaye Ghamkhar. A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature[J]. Chinese Chemical Letters, ;2008, 19(6): 639-642. doi: 10.1016/j.cclet.2008.03.027 shu

A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature

Department of Chemistry, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Ivan

Received Date: 5 November 2007

2,5-Di-substituted 1,3,4-oxadiazoles 3a-n have been synthesized as a one pot procedure from the reaction of acid hydrazide 1, acyl halides 2 and phosphorus pentoxide in acetonitrile at room temperature. High yield, short reaction time (10-15 min), mild condition, and easy work-up are advantages of this methodology.
- 1,3,4-Oxadiazole,
- Acid hydrazide,
- Acyl halide,
- Phosphorus pentoxide
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