Citation: Bai Ling Xu, Jin Ping Chen, De Cai Fu. Facile and efficient synthesis of 2-substituted-N₁-carbethoxy-2, 3-dihydro-4(1H)-quinazolinones in fluorous solvent[J]. Chinese Chemical Letters, ;2008, 19(5): 537-540. doi: 10.1016/j.cclet.2008.03.022 shu

Facile and efficient synthesis of 2-substituted-N₁-carbethoxy-2, 3-dihydro-4(1H)-quinazolinones in fluorous solvent

a Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China;
b Hebei University of Science and Technology, Shijiazhuang 050018, China;
c Department of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

Received Date: 16 January 2008

Fund Project: We are grateful to the National Natural Science Foundation of China (No.30672540) and the Natural Science Foundation of Beijing (No.7072048) for financial support.

A facile, efficient and novel approach to access 2-substituted-N₁-carbethoxy-2,3-dihydro-4(1H)-quinazolinones was developedby condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2-trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.
- Quinazolinones,
- Trifluoroethanol,
- Hexafluoroisopropanol,
- Fhiorous solvent,
- Solvent effect
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