Citation: Shi Fei Sheng, Hui Xia Zheng, Jiang Liu, Zheng Bao Zhao. Synthesis of phenol-class azo derivatives of 4-aminosalicylic acid[J]. Chinese Chemical Letters, ;2008, 19(4): 419-422. doi: 10.1016/j.cclet.2008.01.042 shu

Synthesis of phenol-class azo derivatives of 4-aminosalicylic acid

a School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China;
b First Clinical College, Shanxi Medical University, Taiyuan 030001, China

Received Date: 19 November 2007

To explore the better prodrug of 4-aminosalicylic acid (4-ASA) with higher activity and less side effects against the inflammatory bowel disease.4-ASA, after a succession of synthesis process, was conjugated with various carrier molecules to get seven azo derivatives of 4-ASA.All compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR spectras in detail.New derivatives of 4-ASA were definituded.
- 4-Aminosalicylic acid,
- Azo derivatives of 4-aminosalicylic acid,
- Inflammatory bowel disease
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