Citation: Rui Qing Xian, Shu Tao Ma, Bo Jiao. Synthesis of novel 15-membered macrolide derivatives[J]. Chinese Chemical Letters, ;2008, 19(4): 409-411. doi: 10.1016/j.cclet.2008.01.040 shu

Synthesis of novel 15-membered macrolide derivatives

School of Pharmacy, Shandong University, Jinan 250012, China

Received Date: 5 November 2007

Fund Project: The project was supported by NNSFC (No. 20372043), Shandong Science and Technology Promotion Project (No. 2005GG3202098) and Natural Science Foundation of Shandong Province (No. Y2006C31).

In order to develop new antibiotics effective against resistant bacteria, a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11, C-12 and C-4" positions.Their structures were confirmed by MS, IR, ¹H NMR or ¹³C NMR.
- Macrolide,
- Azithromycin derivatives,
- Synthesis,
- 4"-Carbamate derivatives
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