Citation: Chuan Jin Hou, Xiao Mei Liang, Jing Ping Wu, Dao Quan Wang. Synthesis of macrocyclic lactones with methoxysulfonyl side chain[J]. Chinese Chemical Letters, ;2008, 19(4): 403-405. doi: 10.1016/j.cclet.2008.01.039 shu

Synthesis of macrocyclic lactones with methoxysulfonyl side chain

Key Lab of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100094, China

Received Date: 29 October 2007

Fund Project: The authors are grateful for the financial supports from the National Basic Research Program of China (No. 2003CB114407).

Two representative macrocyclic lactones with methoxysulfonyl side chain (5a and 5b) were synthesized employing Michael addition with acrolein and ring enlargement as the key steps, starting from potassium α-oxocycloalkylsulfonates (1) in total yields of 45 and 57%, respectively.
- Macrocyclic lactone,
- Ring enlargement,
- α-Hydroxypropyl-α-methoxysulfonylcycloalkanones,
- Synthesis
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