Citation: Xing Zhou Li, Xian Ping Dai, Kang Ying Lai, Li Li Wang, Zhi Bing Zheng, Song Li. Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5[J]. Chinese Chemical Letters, ;2008, 19(4): 379-382. doi: 10.1016/j.cclet.2008.01.032 shu

Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5

a Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China;
b School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 19 October 2007

Fund Project: This work was supported by a grant from the National High Technology Research and Development Program of China (2006AA10A201).

A series of 2, 4, 5-triaryl substituted 1H-pyrazol-3(2H)-ones, as ALK5 inhibitors, were desigened, synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1 μmol/L and displayed no significant cytotoxicities at 30 μmol/L.
- Activin-like kinases5 (ALK5),
- Kinase inhibitors,
- 1H-Pyrazol-3(2H)-ones
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