Citation: Yao Liu, Jing Su, Jun Hai Xiao, Shi Bo Jiang, Hong Lu, Wu Zhong, Li Li Wang, Xiao Hong Yang, Song Li. Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity[J]. Chinese Chemical Letters, ;2008, 19(4): 428-430. doi: 10.1016/j.cclet.2008.01.029 shu

Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity

Yao Liu ^a,c, ,
Jing Su ^b ,
Jun Hai Xiao ^c ,
Shi Bo Jiang ^d ,
Hong Lu ^d ,
Wu Zhong ^c ,
Li Li Wang ^c ,
Xiao Hong Yang ^a ,
Song Li ^c

a School of Pharmacy, Jilin University, Changchun 130021, China;
b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
c Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;
d Lindsley F. Kimball Research Institute, The New York Blood Center, New York, NY 10021, USA

Received Date: 3 December 2007

Fund Project: This work was supported by the National Basic Research Program of China (No. 2004CB518908) and the National Natural Science Foundation of China (No. 30472093) to SL and the Outstanding Overseas Chinese Scholars Fund of Chinese Academy of Sciences (No. 2005-2-6) to SJ. We thank Professor A. Carrieri for providing CCR5 model.

A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and ¹H-NMR.These compounds exhibited potent anti-HIV-1 activities.
- HIV-1 entry inhibitors,
- Benzoeycloheptene derivatives,
- Synthesis
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