Citation: Jiao Wang, Ying Zhong, Lu Liu, Xin Quan Ji, Zhi Guo Zhang. Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone[J]. Chinese Chemical Letters, ;2008, 19(4): 387-389. doi: 10.1016/j.cclet.2008.01.024 shu

Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

a Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China;
b The National Center for Drug Screening, Shanghai 201203, China;
c Pharmacological Institute of New Drugs, School of Pharmacy, Shandong University, Jinan 250012, China

Received Date: 22 October 2007

Fund Project: This work is by part supported by the National Center for Drug Screening. We thank Dr Zhiguo Zhang for useful discussions.

Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated.Compounds 2a, 2b, 2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.
- Irisolidone,
- Mannich reaction,
- Mannich base,
- Nitric oxide (NO) production inhibition
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