Citation: Ai Jun Li, Xiao Hua Zhang, Xue Qin Zhou, Dong Zhi Liu. New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives: Synthesis and evaluation for dual 5-HT_1A/SSRI activities[J]. Chinese Chemical Letters, ;2008, 19(4): 412-414. doi: 10.1016/j.cclet.2008.01.017 shu

New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives: Synthesis and evaluation for dual 5-HT_1A/SSRI activities

a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China

Received Date: 8 November 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20576094). We also thank Prof. Naihong Chen for determining affinity to 5-HTT and 5-HT1A receptor.

A series of 3-(4-arylpiperazin-1-yl)-l-(benzo[b]thiopben-3-yl)-2-methylpropanol derivatives were designed and synthesized based on 5-HT_1A/SSRI drugs design strategies.The synthesized compounds were evaluated for their dual 5-HT_1A/5-HTT activities.
- Antidepressants,
- Arylpiperazines,
- 5-HT_1A/SSRI,
- 5-HT transporter,
- 5-HT_1A receptor
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