Citation: Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, Xue Qin Zhou. N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines: Synthesis and evaluation for dual 5-HT_1A/SSRI activities[J]. Chinese Chemical Letters, ;2008, 19(3): 295-298. doi: 10.1016/j.cclet.2008.01.016 shu

N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines: Synthesis and evaluation for dual 5-HT_1A/SSRI activities

a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China

Received Date: 5 November 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20576094). We also thank Prof. Chen Naihong for determining affinity at the 5-HTT and 5-HT1A receptor.

The design, synthesis and biological evaluation of N-(2-(2-methoxyphenylthio) benzyl)-2-aryloxyethyl amines with dual 5-HT_1A/SSRI activities are reported. Compound 8e displays the best dual activities and is a promising lead compound for further SAR studies.
- Antidepressants,
- 5-HT_1A/5-HTT,
- 5-HT_1A receptor,
- Diphenylsulfide,
- Aryloxyethylamines
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