Citation: Wei Guo, Lv Yin Zheng, Yong Quan Wu, Xiao Lin Fan. Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide[J]. Chinese Chemical Letters, ;2008, 19(4): 406-408. doi: 10.1016/j.cclet.2008.01.014 shu

Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide

Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China

Received Date: 5 November 2007

Fund Project: The authors are grateful for the financial support from National Natural Science Foundation of China (Nos. 50478117, 50568001). Supports from the invite public important bidding project of Jiangxi province (2006) and science foundation of Jiangxi provincial Department Education (No. GJJ08385) are also acknowledged.

A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae larvae.These compounds were derived from niphensamide.While the compounds were dropped on the surface of water, the liquor diffused along the air-water interface and formed thin membranes floating on the water surface immediately.The strong cercaricidal activities against the cercariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments.
- Niphensamide,
- Self-diffused cercaricide,
- Cercariae larvae
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