Alkaloids from the root barks of Goniothalamus cheliensis

Miao Miao Jiang ^a, ,
Xue Zhang ^b ,
Yi Dai ^c ,
Hao Gao ^b,c ,
Hong Wei Liu ^d ,
Nai Li Wang ^b ,
Wen Cai Ye ^c ,
Xin Sheng Yao ^a,c

a College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China;
b Key Lab for New Drugs Research of TCM, Shenzhen Research Institute of Tsinghua University, Shenzhen 518055, China;
c Institutes of Traditional Chinese Medicine and Natural Product, Jinan University, Guangzhou 510632, China;
d School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Science, Beijing 100069, China

Received Date: 8 October 2007

Fund Project: This work was supported by grants from the National Natural Science of Foundation of PR China (No. 30600777) and China Postdoctoral Science Foudation (No. 20070410245).

(3S)-2-Oxo-5, 12-dimethoxy-3-hydroxy-3-methylbenz[f]indoline (1), a new benzoxindole alkaloid, along with two known alkaloids, was isolated from the root barks of Goniothalamus cheliensis Hu. The structure was elucidated by spectroscopic evidences, and the absolute configuration was determined by CD spectrum.

Alkaloids from the root barks of Goniothalamus cheliensis

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