Citation: Jia Di Huang, Xiang Ping Hu, Zhuo Zheng. Synthesis of novel chiral phosphine-triazine ligand derived from α-phenylethylamine for Pd-catalyzed asymmetricallylic alkylation[J]. Chinese Chemical Letters, ;2008, 19(3): 261-263. doi: 10.1016/j.cclet.2007.12.027 shu

Synthesis of novel chiral phosphine-triazine ligand derived from α-phenylethylamine for Pd-catalyzed asymmetricallylic alkylation

a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China;
b Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China

Received Date: 26 August 2007

Fund Project: The authors would like to thank the National Natural Science Foundation of China (No. 20472083) for financial support.

A novel chiral phosphine-triazine ligand was synthesized from chiral α-phenylethylamine through a three-step procedure. In a model reaction of Pd-catalyzed allylic alkylation of rac-1, 3-diphenylprop-2-en-1-yl pivalate with dimethyl malonate, good enantioselectivity (90% e.e.) was obtained by using this ligand.
- Synthesis,
- α-Phenylethylamine,
- Phosphine-triazine ligand,
- Pd-catalyzed allylic alkylation
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