Citation: Xiang Wei Liao, Bao He Guan, Zhan Zhu Liu. A new and efficient method for the synthesis of isoquinoline-3-carboxylate[J]. Chinese Chemical Letters, ;2008, 19(3): 253-255. doi: 10.1016/j.cclet.2007.12.025 shu

A new and efficient method for the synthesis of isoquinoline-3-carboxylate

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China

Received Date: 5 November 2007

Fund Project: We thank the National Natural Sciences Foundation of China (No. 30672518) and Specialized Research Fund for the Doctoral Program of Higher Education (No. 20060023025) for financial support.

An isoquinoline-3-carboxylate compound 3 was obtained with a moderate yield of 40% when N-acetyl-(3'-hydroxy-4'-methoxy-5'-methyl) phenylalanine methyl ester 1 was refluxed in HMTA/TFA. However, the anticipated product N-acetyl-(3'-hydroxy-4'-methoxy-5'-methyl-6'-formyl) phenylalanine methyl ester 2 could not be found. The possible mechanism was discussed in this article.
- Isoquinoline-3-carboxylate,
- Duff reaction,
- N-acetyl-phenylalanine methyl ester
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