Citation: Qing Lin Jiang, Li Hai, Lei Chen, Jiao Lu, Zhi Rong Zhang, Yong Wu. Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery[J]. Chinese Chemical Letters, ;2008, 19(2): 127-129. doi: 10.1016/j.cclet.2007.12.002 shu

Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery

Key Laboratory of Drug Targeting of Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 20 June 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30672537) and Ministry of Education of PR China (No. 20050610085).

A novel bifunctional glycolipid which carried a cluster of thiogalactosides as the bepatocyte targeting ligand for gene delivery was prepared.Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly (ethylene glycol) chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galaetoside.Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.
- Clustered glycosides,
- Targeting,
- Galactosylated ligand,
- Hepatocyte,
- Gene delivery
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