Citation: Xin Zhai, Juan Li, Lei He, Su Zheng, Yao Bin Zhang, Ping Gong. Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines[J]. Chinese Chemical Letters, ;2008, 19(1): 29-32. doi: 10.1016/j.cclet.2007.11.018 shu

Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines

Xin Zhai ^a, ,
Juan Li ^b ,
Lei He ^a ,
Su Zheng ^a ,
Yao Bin Zhang ^a ,
Ping Gong ^a

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b Shenyang No. 1 Pharmaceutical Factory, Northeast Pharmaceutical Group Co., Ltd., Shenyang 110023, China

Received Date: 27 August 2007

Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, ¹H NMR,¹³C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potentcytotoxicity than cisplatin.
- Phthalazine derivatives,
- Synthesis,
- Cytotoxicity
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