Citation: Yan Yan Liu, Sheng Qin Xia, Zhang Hua Zeng, Rui Qiao, Xue Song Wang, Bao Wen Zhang. Synthesis of a hypocrellin B-polyamide conjugate as DNA-targeting photosensitizer[J]. Chinese Chemical Letters, ;2008, 19(2): 157-160. doi: 10.1016/j.cclet.2007.11.013 shu

Synthesis of a hypocrellin B-polyamide conjugate as DNA-targeting photosensitizer

a Lab of Organic Optoelectronic Functional Materials and Molecular Engineering, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China;
b Graduate School of Chinese Academy of Sciences, Beijing 100049, PR China

Received Date: 26 September 2007

Fund Project: This work was financially supported by NNSFC (No. 20772133) and the Chinese Academy of Sciences (No. KJCX2.YW.H08).

A new hypocrellin B (HB) derivative bearing a bispyrrolecarboxamide-containing side chain was synthesized, which presents improved absorptivity in phototherapeutic window than Hb and affinity feature towards dsDNA.
- Hypocrellin,
- Polyamide,
- Groove binding,
- DNA affinity
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