Citation: Lu Liu, Peng Xu, Liang Zhou, Ping Sheng Lei. Synthesis of derivatives of imidazo[4,5-b] pyridine: Novel sulfur contained side chains for macrolide antibiotics[J]. Chinese Chemical Letters, ;2008, 19(1): 1-4. doi: 10.1016/j.cclet.2007.11.012 shu

Synthesis of derivatives of imidazo[4,5-b] pyridine: Novel sulfur contained side chains for macrolide antibiotics

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100050, China

Received Date: 20 September 2007

Fund Project: Finacial support of this research by the National Natural Science Foundation of China(No.30572275) and Natural Science Foundation of Beijing(No.7062047) are gratefully acknowledged by the authors.

Two series of novel derivatives of imidazo[4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ¹H, ¹³C NMR, MS, HMBC spectra.
- Macrolide,
- Heterarylalkyl sulfur contained side chain,
- Imidazo[4,5-b]pyddine,
- Synthesis,
- HMBC
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