Citation: Jing Su, Yao Liu, Zhi Bing Zheng, Jun Hai Xiao, Hong Lu, Wu Zhong, Li Li Wang, Shi Bo Jiang, Song Li. Synthesis of aromatic-linked polyamine macrocyclic derivatives as HIV-1 entry inhibitors[J]. Chinese Chemical Letters, ;2007, 18(10): 1166-1168. doi: 10.1016/j.cclet.2007.08.021 shu

Synthesis of aromatic-linked polyamine macrocyclic derivatives as HIV-1 entry inhibitors

Jing Su ^a, ,
Yao Liu ^b ,
Zhi Bing Zheng ^c ,
Jun Hai Xiao ^c ,
Hong Lu ^b ,
Wu Zhong ^c ,
Li Li Wang ^c ,
Shi Bo Jiang ^b ,
Song Li ^c

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b School of Pharmacy, Jilin University, Changchun 130021, China;
c Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;
d Lindsley F. Kimball Research Institute, the New York Blood Center, New York, NY 10021, USA

Received Date: 13 June 2007

Fund Project: This work was supported by the National Basic Research Program of China (973 project:No.2004CB518908) and the National Natural Science Foundation of China (No.30472093) to SL and the Outstanding Overseas Chinese Scholars Fund of Chinese Academy of Sciences (No.2005-2-6) to S.J.

A series of novel aromatic-linked polyamine macrocyclic derivatives have been synthesized, Their structures were confirmed by MS and ¹H NMR. These compounds exhibited potent anti-HIV-1 activities.
- HIV-1 entry inhibitors,
- Aromatic-linked polyamine,
- Macrocyclic derivatives,
- Synthesis
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