Citation: Qiu Qin He, Ke Li, Yong Bing Cao, Huan Wen Dong, Li Hua Zhao, Chao Mei Liu, Chun Quan Sheng. Design, synthesis and molecular docking studies of novel triazole antifungal compounds[J]. Chinese Chemical Letters, ;2007, 18(6): 663-666. doi: 10.1016/j.cclet.2007.04.025 shu

Design, synthesis and molecular docking studies of novel triazole antifungal compounds

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 8 January 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20672140).

Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized.In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities.In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.
- Lanosterol 14α-demethylase,
- Triazole,
- tert-Butyl,
- Antifungal activity,
- Fluconazole-resistant
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