Citation: Jin Yong Peng, Hai Yan Liu, Yan Qi, Xu Han, You Wei Xu, Li Na Xu, Qi Wei Xu. A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib[J]. Chinese Chemical Letters, ;2007, 18(3): 293-296. doi: 10.1016/j.cclet.2007.01.007 shu

A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib

Jin Yong Peng ^a, ,
Hai Yan Liu ^b ,
Yan Qi ^a ,
Xu Han ^a ,
You Wei Xu ^a ,
Li Na Xu ^a ,
Qi Wei Xu ^a

a School of Pharmacy, Dalian Medical University, Dalian 116027, China;
b People's Hospital of the State of Xishuangbanna, Yunnan 666100, China

Received Date: 10 October 2006

Fund Project: The authors thank Dr. Genjin Yang (Second Military Medical University,Shanghai,China) for his performing 1D and 2D NMR experiments.

A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2',6'-trihydroxy-3''', 8-di (γ, γ-dimethyl-allyl)-2''', 2'''-dimethylpyrano-[5''',6''':6,7]-2''''',4'''''-cyclohexadiene-1'''''-one-[2''''',3''''':3',4']-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.
- Dolichos tenuicaulis(Baker)Craib,
- Prenylated dihydroflavonoid,
- Anticancer activity
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