Citation: Juan Huang, Jian Wei Wang, Tao Gong, Zhi Rong Zhang. Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach[J]. Chinese Chemical Letters, ;2007, 18(3): 247-250. doi: 10.1016/j.cclet.2006.12.026 shu

Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach

Key Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 30 June 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30430770).

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.
- Insulin,
- 5-Fluorouracil,
- Prodrug,
- Characterization,
- Stability
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