Four new eremophilendiolides from Ligularia atroviolacea

a Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China;
b College of Pharmacy, Kunming College of Medicine, Kunming, China;
c Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
d Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany

Received Date: 6 March 2006

Fund Project: This work is by part financially supported by DAAD-CSC PPP project (CSC[2004]3067) and Special 985 Foundation from Zhejiang University.We thank Dr. FrancÇritte (Gif-sur-Yvette) for useful discussions. One of the authors (Y. Zhao) would also like to express his thankfulness to the Chinese Ministry of Education as well as to Mr. Kashing Li for the Cheung Kong Scholars Chair Professorship at Zhejiang University.oise Gueé

From Ligularia atroviolacea, four new eremophilendiolides, 8β-hydroxy-eremophil-3,7 (11)-dien-12,8α(14,6α)-diolide (1),8β-methoxy-eremophil-3,7(11)-dien-12,8α(14,6α)-diolide (2), 8α-hydroxy-eremophil-3,7(11)-dien-12,8β(14,6α)-diolide (3) and eremophil-3,7(11),8-trien-12,8 (14,6α)-diolide (4), as well as a known diolide (5) were isolated. Their structures were elucidated on the basis of 1D and 2D NMR as well as ESI-MS spectral data.

Four new eremophilendiolides from Ligularia atroviolacea

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