Membrane-anchoring nanoengineered carbon dots as a pyroptosis amplifier for robust tumor photodynamic-immunotherapy
- Corresponding author: Haihua Xiao, hhxiao@iccas.ac.cn Jiechao Ge, jchge2010@mail.ipc.ac.cn
 
	            Citation:
	            
		            Tiejin Chen, Xiaokuang Xue, Jian Li, Minhui Cui, Yongliang Hao, Mianqi Xue, Haihua Xiao, Jiechao Ge, Pengfei Wang. Membrane-anchoring nanoengineered carbon dots as a pyroptosis amplifier for robust tumor photodynamic-immunotherapy[J]. Acta Physico-Chimica Sinica,
							;2025, 41(10): 100113.
						
							doi:
								10.1016/j.actphy.2025.100113
						
					
				
					
				
	        
	                
				Y. Wang, K. Ma, M. Kang, D. Yan, N. Niu, S. Yan, P. Sun, L. Zhang, L. Sun, D. Wang, et al., Chem. Soc. Rev. 53 (2024) 12014, https://doi.org/10.1039/D4CS00708E.
												 doi: 10.1039/D4CS00708E
											
										
				E. Nestoros, A. Sharma, E. Kim, J. S. Kim, M. Vendrell, Nat. Rev. Chem. 9 (2025) 46, https://doi.org/10.1038/s41570-024-00662-7.
												 doi: 10.1038/s41570-024-00662-7
											
										
				T. C. Pham, V. N. Nguyen, Y. Choi, S. Lee, J. Yoon, Chem. Rev. 121 (2021) 13454, https://doi.org/10.1021/acs.chemrev.1c00381.
												 doi: 10.1021/acs.chemrev.1c00381
											
										
				J. Kang, H. Jeong, M. Jeong, J. Kim, S. Park, J. Jung, J. M. An, D. Kim, J. Am. Chem. Soc. 145 (2023) 27587, https://doi.org/10.1021/jacs.3c09339.
												 doi: 10.1021/jacs.3c09339
											
										
				L. Li, X. Zhang, Y. Ren, Q. Yuan, Y. Wang, B. Bao, M. Li, Y. Tang, J. Am. Chem. Soc. 146 (2024) 5927, https://doi.org/10.1021/jacs.3c12132.
												 doi: 10.1021/jacs.3c12132
											
										
				X. Qu, F. Yin, M. Pei, Q. Chen, Y. Zhang, S. Lu, X. Zhang, Z. Liu, X. Li, H. Chen, et al., ACS Nano 17 (2023) 11466, https://doi.org/10.1021/acsnano.3c01308.
												 doi: 10.1021/acsnano.3c01308
											
										
				L. Feng, D. Tao, Z. Dong, Q. Chen, Y. Chao, Z. Liu, M. Chen, Biomaterials 127 (2017) 13, https://doi.org/10.1016/j.biomaterials.2016.11.027.
												 doi: 10.1016/j.biomaterials.2016.11.027
											
										
				X. Zhang, J. Xiong, K. Wang, H. Yu, B. Sun, H. Ye, Z. Zhao, N. Wang, Y. Wang, S. Zhang, et al., Bioact. Mater. 6 (2021) 2291, https://doi.org/10.1016/j.bioactmat.2021.01.004.
												 doi: 10.1016/j.bioactmat.2021.01.004
											
										
				M. Dirak, C. M. Yenici, S. Kolemen, Coord. Chem. Rev. 506 (2024) 215710, https://doi.org/10.1016/j.ccr.2024.215710.
												 doi: 10.1016/j.ccr.2024.215710
											
										
				J. B. Zhuang, Z. D. Ma, N. Li, H. Chen, L. J. Yang, Y. Lu, K. Y. Guo, N. Zhao, B. Z. Tang, Adv. Mater. 36 (2024) 2309488, https://doi.org/10.1002/adma.202309488.
												 doi: 10.1002/adma.202309488
											
										
				F. H. Igney, P. H. Krammer, Nat. Rev. Cancer 2 (2002) 277, https://doi.org/10.1038/nrc776.
												 doi: 10.1038/nrc776
											
										
				K. Hadian, B. R. Stockwell, Nat. Rev. Drug Discov. 22 (2023) 723, https://doi.org/10.1038/s41573-023-00749-8.
												 doi: 10.1038/s41573-023-00749-8
											
										
				X. Sun, M. Li, P. Wang, Q. Bai, X. Cao, D. Mao, Small Methods 7 (2023) 2201614, https://doi.org/10.1002/smtd.202201614.
												 doi: 10.1002/smtd.202201614
											
										
				W. T. Gao, X. Y. Wang, Y. Zhou, X. Q. Wang, Y. Yu, Sig. Transdut. Target. Ther. 7 (2022) 196, https://doi.org/10.1038/s41392-022-01046-3.
												 doi: 10.1038/s41392-022-01046-3
											
										
				P. Fontana, G. Du, Y. Zhang, H. Zhang, S. M. Vora, J. J. Hu, M. Shi, A. B. Tufan, L. B. Healy, S. Xia, et al., Cell 187 (2024) 6165, https://doi.org/10.1016/j.cell.2024.08.007.
												 doi: 10.1016/j.cell.2024.08.007
											
										
				Q. Y. Wang, Y. P. Wang, J. J. Ding, C. H. Wang, X. H. Zhou, W. Q. Gao, H. W. Huang, F. Shao, Z. B. Liu, Nature 579 (2020) 421, https://doi.org/10.1038/s41586-020-2079-1.
												 doi: 10.1038/s41586-020-2079-1
											
										
				Z. B. Zhang, Y. Zhang, S. Y. Xia, Q. Kong, S. Y. Li, X. Liu, C. Junqueira, K. F. Meza-Sosa, T. M. Y. Mok, J. Ansara, et al., Nature 579 (2020) 415, https://doi.org/10.1038/s41586-020-2071-9.
												 doi: 10.1038/s41586-020-2071-9
											
										
				Z. He, D. Feng, C. Zhang, Z. Chen, H. Wang, J. Hou, S. Li, X. Wei, J. Control. Release 366 (2024) 375, https://doi.org/10.1016/j.jconrel.2023.12.023.
												 doi: 10.1016/j.jconrel.2023.12.023
											
										
				M. Wu, X. G. Liu, H. Chen, Y. K. Duan, J. J. Liu, Y. T. Pan, B. Liu, Angew. Chem. Int. Ed. 60 (2021) 9093, https://doi.org/10.1002/anie.202016399.
												 doi: 10.1002/anie.202016399
											
										
				M. Li, J. Kim, H. Rha, S. Son, M. S. Levine, Y. Xu, J. L. Sessler, J. S. Kim, J. Am. Chem. Soc. 145 (2023) 6007, https://doi.org/10.1021/jacs.3c01231.
												 doi: 10.1021/jacs.3c01231
											
										
				M. Wang, M. Wu, X. Liu, S. Shao, J. Huang, B. Liu, T. Liang, Adv. Sci. 9 (2022) 2202914, https://doi.org/10.1002/advs.202202914.
												 doi: 10.1002/advs.202202914
											
										
				Z. G. Yi, X. J. Qin, L. Zhang, H. Chen, T. L. Song, Z. C. Luo, T. Wang, J. Lau, Y. L. Wu, T. B. Toh, et al., J. Am. Chem. Soc. 146 (2024) 9413, https://doi.org/10.1021/jacs.4c01929.
												 doi: 10.1021/jacs.4c01929
											
										
				Q. Liu, X. Yao, L. Zhou, W. Wu, J. Cheng, Z. Zhang, Z. Li, H. Sun, J. Jin, M. Zhang, et al., Adv. Mater. 36 (2024) 2401145, https://doi.org/10.1002/adma.202401145.
												 doi: 10.1002/adma.202401145
											
										
				X. Wu, J. J. Hu, J. Yoon, Angew. Chem. Int. Ed. 63 (2024) e202400249, https://doi.org/10.1002/anie.202400249.
												 doi: 10.1002/anie.202400249
											
										
				C. Xiang, Y. Liu, Q. Ding, T. Jiang, C. Li, J. Xiang, X. Yang, T. Yang, Y. Wang, Y. Tan, et al., Adv. Funct. Mater. 35 (2024) 2417979, https://doi.org/10.1002/adfm.202417979.
												 doi: 10.1002/adfm.202417979
											
										
				Z. Li, F. Mo, Y. Wang, W. Li, Y. Chen, J. Liu, T. -J. Chen-Mayfield, Q. Hu, Nat. Commun. 13 (2022) 6321, https://doi.org/10.1038/s41467-022-34036-8.
												 doi: 10.1038/s41467-022-34036-8
											
										
				Y. Q. Tang, H. K. Bisoyi, X. M. Chen, Z. Y. Liu, X. Chen, S. Zhang, Q. Li, Adv. Mater. 35 (2023) 2300232, https://doi.org/10.1002/adma.202300232.
												 doi: 10.1002/adma.202300232
											
										
				Y. Liu, Z. Huang, X. Wang, Y. Hao, J. Yang, H. Wang, S. Qu, Adv. Funct. Mater. 35 (2025) 2420587, https://doi.org/10.1002/adfm.202420587.
												 doi: 10.1002/adfm.202420587
											
										
				B. Y. Wang, S. Y. Lu, Matter 5 (2022) 110, https://doi.org/10.1016/j.matt.2021.10.016.
												 doi: 10.1016/j.matt.2021.10.016
											
										
				L. Jiang, H. Cai, W. W. Zhou, Z. J. Li, L. Zhang, H. Bi, Adv. Mater. 35 (2023) 2210776, https://doi.org/10.1002/adma.202210776.
												 doi: 10.1002/adma.202210776
											
										
				J. C. Ge, M. H. Lan, B. J. Zhou, W. M. Liu, L. Guo, H. Wang, Q. Y. Jia, G. L. Niu, X. Huang, H. Y. Zhou, et al., Nat. Commun. 5 (2014) 4596, https://doi.org/10.1038/ncomms5596.
												 doi: 10.1038/ncomms5596
											
										
				S. H. Li, W. Su, H. Wu, T. Yuan, C. Yuan, J. Liu, G. Deng, X. C. Gao, Z. M. Chen, Y. M. Bao, et al. , Nat. Biomed. Eng. 4 (2020) 704, https://doi.org/10.1038/s41551-020-0540-y.
												 doi: 10.1038/s41551-020-0540-y
											
										
				L. Ðorđević, F. Arcudi, M. Cacioppo, M. Prato, Nat. Nanotechnol. 17 (2022) 112, https://doi.org/10.1038/s41565-021-01051-7.
												 doi: 10.1038/s41565-021-01051-7
											
										
				T. Han, Y. Wang, S. Ma, M. Li, N. Zhu, S. Tao, J. Xu, B. Sun, Y. Jia, Y. Zhang, et al., Adv. Sci. 9 (2022) 2203474, https://doi.org/10.1002/advs.202203474.
												 doi: 10.1002/advs.202203474
											
										
				H. Sun, S. Sun, H. Wang, K. Cheng, Y. Zhou, X. Wang, S. Gao, J. Mo, S. Li, H. Lin, et al., Acta Biomater. 194 (2025) 352, https://doi.org/10.1016/j.actbio.2025.01.030.
												 doi: 10.1016/j.actbio.2025.01.030
											
										
				Y. Zhang, Q. Jia, F. Nan, J. Wang, K. Liang, J. Li, X. Xue, H. Ren, W. Liu, J. Ge, et al., Biomaterials 293 (2023) 121953, https://doi.org/10.1016/j.biomaterials.2022.121953.
												 doi: 10.1016/j.biomaterials.2022.121953
											
										
				X. Zhang, L. Li, B. Wang, Z. Cai, B. Zhang, F. Chen, G. Xing, K. Li, S. Qu, Angew. Chem. Int. Ed. 63 (2024) e202410522, https://doi.org/10.1002/anie.202410522.
												 doi: 10.1002/anie.202410522
											
										
				B. Wang, G. I. N. Waterhouse, B. Yang, S. Lu, Acc. Chem. Res. 57 (2024) 2928, https://doi.org/10.1021/acs.accounts.4c00516.
												 doi: 10.1021/acs.accounts.4c00516
											
										
				Q. Cheng, T. Zhang, Q. Wang, X. Wu, L. Li, R. Lin, Y. Zhou, S. Qu, Adv. Mater. 36 (2024) 2408685, https://doi.org/10.1002/adma.202408685.
												 doi: 10.1002/adma.202408685
											
										
				T. Chen, K. Liang, J. Wang, J. Li, X. Xue, Y. Hao, H. Liang, H. Ren, H. Xiao, J. Ge,  et al., Nano Lett. 24 (2024) 14709, https://doi.org/10.1021/acs.nanolett.4c03913.
												 doi: 10.1021/acs.nanolett.4c03913
											
										
				J. Yang, B. Ren, X. Yin, L. Xiang, Y. Hua, X. Huang, H. Wang, Z. Mao, W. Chen, J. Deng, Adv. Mater. 36 (2024) 2402720, https://doi.org/10.1002/adma.202402720.
												 doi: 10.1002/adma.202402720
											
										
				Y. J. Li, Y. C. Guo, K. X. Zhang, R. R. Zhu, X. Y. Chen, Z. Z. Zhang, W. J. Yang, Adv. Sci. 11 (2024) 2306580, https://doi.org/10.1002/advs.202306580.
												 doi: 10.1002/advs.202306580
											
										
				J. Xu, X. Zheng, T. -B. Ren, L. Shi, X. Yin, L. Yuan, X. -B. Zhang, Coord. Chem. Rev. 528 (2025) 216379, https://doi.org/10.1016/j.ccr.2024.216379.
												 doi: 10.1016/j.ccr.2024.216379
											
										
				Y. Li, D. Hu, M. Pan, Y. Qu, B. Chu, J. Liao, X. Zhou, Q. Liu, S. Cheng, Y. Chen, et al., Biomaterials 288 (2022) 121700, https://doi.org/10.1016/j.biomaterials.2022.121700.
												 doi: 10.1016/j.biomaterials.2022.121700
											
										
				D. -T. Nguyen, M. -J. Baek, S. M. Lee, D. Kim, S. -Y. Yoo, J. -Y. Lee, D. -D. Kim, Nat. Nanotechnol. 19 (2024) 1723, https://doi.org/10.1038/s41565-024-01757-4.
												 doi: 10.1038/s41565-024-01757-4
											
										
				M. Yu, S. Li, X. Ren, N. Liu, W. Guo, J. Xue, L. Tan, C. Fu, Q. Wu, M. Niu, et al., ACS Nano 18 (2024) 3636, https://doi.org/10.1021/acsnano.3c11433.
												 doi: 10.1021/acsnano.3c11433
											
										
				H. Xia, W. Zhou, D. Li, F. Peng, L. Yu, Y. Sang, H. Liu, A. Hao, J. Qiu, Angew. Chem. Int. Ed. 63 (2024) e202312755, https://doi.org/10.1002/anie.202312755.
												 doi: 10.1002/anie.202312755
											
										
				T. Zhang, X. Yang, X. Ou, M. M. S. Lee, J. Zhang, C. Xu, X. Yu, P. Gong, J. W. Y. Lam, P. Zhang, et al., Adv. Mater. 35 (2023) 2303186, https://doi.org/10.1002/adma.202303186.
												 doi: 10.1002/adma.202303186
											
										
				L. H. Liu, W. X. Qiu, Y. H. Zhang, B. Li, C. Zhang, F. Gao, L. Zhang, X. Z. Zhang, Adv. Funct. Mater. 27 (2017) 1700220, https://doi.org/10.1002/adfm.201700220.
												 doi: 10.1002/adfm.201700220
											
										
				S. J. Hao, Y. X. Zhu, F. G. Wu, J. Control. Release. 357 (2023) 222, https://doi.org/10.1016/j.jconrel.2023.03.038.
												 doi: 10.1016/j.jconrel.2023.03.038
											
										
				K. Minton, Nat. Rev. Mmunol. 20 (2020) 274, https://doi.org/10.1038/s41577-020-0297-2.
												 doi: 10.1038/s41577-020-0297-2
											
										
						
						
						
	                Xue Wu , Yupeng Liu , Bingzhe Wang , Lingyun Li , Zhenjian Li , Qingcheng Wang , Quansheng Cheng , Guichuan Xing , Songnan Qu . Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy. Acta Physico-Chimica Sinica, 2025, 41(9): 100109-0. doi: 10.1016/j.actphy.2025.100109
Wenli FENG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress on ultralong room temperature phosphorescent carbon dots. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 833-846. doi: 10.11862/CJIC.20240308
Qianli Ma , Tianbing Song , Tianle He , Xirong Zhang , Huanming Xiong . Sulfur-doped carbon dots: a novel bifunctional electrolyte additive for high-performance aqueous zinc-ion batteries. Acta Physico-Chimica Sinica, 2025, 41(9): 100106-0. doi: 10.1016/j.actphy.2025.100106
Chunyuan Kang , Xiaoyu Li , Fan Yang , Bai Yang . Ionic-bond crosslinked carbonized polymer dots for tunable and enhanced room temperature phosphorescence. Acta Physico-Chimica Sinica, 2026, 42(1): 100156-. doi: 10.1016/j.actphy.2025.100156
Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
Qi Wang , Yicong Gao , Feng Lu , Quli Fan . Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment. University Chemistry, 2024, 39(11): 342-349. doi: 10.12461/PKU.DXHX202404141
Rui Gao , Ying Zhou , Yifan Hu , Siyuan Chen , Shouhong Xu , Qianfu Luo , Wenqing Zhang . Design, Synthesis and Performance Experiment of Novel Photoswitchable Hybrid Tetraarylethenes. University Chemistry, 2024, 39(5): 125-133. doi: 10.3866/PKU.DXHX202310050
Yue WANG , Zhizhi GU , Jingyi DONG , Jie ZHU , Cunguang LIU , Guohan LI , Meichen LU , Jian HAN , Shengnan CAO , Wei WANG . Effects of kelp-derived carbon dots on embryonic development of zebrafish. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1209-1217. doi: 10.11862/CJIC.20230423
Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
Shiyi Chen , Jialong Fu , Jianping Qiu , Guoju Chang , Shiyou Hao . Waste medical mask-derived carbon quantum dots enhance the photocatalytic degradation of polyethylene terephthalate (PET) over BiOBr/g-C3N4 S-scheme heterojunction. Acta Physico-Chimica Sinica, 2026, 42(1): 100135-. doi: 10.1016/j.actphy.2025.100135
Kuaibing Wang , Feifei Mao , Weihua Zhang , Bo Lv . Design and Practice of a Comprehensive Teaching Experiment for Preparing Biomass Carbon Dots from Rice Husk. University Chemistry, 2025, 40(5): 342-350. doi: 10.12461/PKU.DXHX202407042
Lingqi Zhang , Hairong Huang , Jialin Li , Li Ji , Yufan Pan , Meiling Ye , Cuixue Chen , Shunü Peng . 桂花碳量子点的绿色制备及科普应用方案. University Chemistry, 2025, 40(8): 298-306. doi: 10.12461/PKU.DXHX202409138
Shiyang He , Dandan Chu , Zhixin Pang , Yuhang Du , Jiayi Wang , Yuhong Chen , Yumeng Su , Jianhua Qin , Xiangrong Pan , Zhan Zhou , Jingguo Li , Lufang Ma , Chaoliang Tan . Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-0. doi: 10.1016/j.actphy.2025.100046
Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
Zeyu XU , Anlei DANG , Bihua DENG , Xiaoxin ZUO , Yu LU , Ping YANG , Wenzhu YIN . Evaluation of the efficacy of graphene oxide quantum dots as an ovalbumin delivery platform and adjuvant for immune enhancement. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1065-1078. doi: 10.11862/CJIC.20240099
Baohua LÜ , Yuzhen LI . Anisotropic photoresponse of two-dimensional layered α-In2Se3(2H) ferroelectric materials. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1911-1918. doi: 10.11862/CJIC.20240105
Chengqian Mao , Yanghan Chen , Haotong Bai , Junru Huang , Junpeng Zhuang . Photodimerization of Styrylpyridinium Salt and Its Application in Silk Screen Printing. University Chemistry, 2024, 39(5): 354-362. doi: 10.3866/PKU.DXHX202312014
Runhua Chen , Qiong Wu , Jingchen Luo , Xiaolong Zu , Shan Zhu , Yongfu Sun . Defective Ultrathin Two-Dimensional Materials for Photo-/Electrocatalytic CO2 Reduction: Fundamentals and Perspectives. Acta Physico-Chimica Sinica, 2025, 41(3): 2308052-0. doi: 10.3866/PKU.WHXB202308052