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合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果

吴雪 ,  刘钰鹏 ,  王冰哲 ,  李凌云 ,  黎镇坚 ,  王青城 ,  程全胜 ,  刑贵川 ,  曲松楠

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引用本文: 吴雪, 刘钰鹏, 王冰哲, 李凌云, 黎镇坚, 王青城, 程全胜, 刑贵川, 曲松楠. 合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果[J]. 物理化学学报, 2025, 41(9): 100109. doi: 10.1016/j.actphy.2025.100109 shu
Citation:  Xue Wu, Yupeng Liu, Bingzhe Wang, Lingyun Li, Zhenjian Li, Qingcheng Wang, Quansheng Cheng, Guichuan Xing, Songnan Qu. Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy[J]. Acta Physico-Chimica Sinica, 2025, 41(9): 100109. doi: 10.1016/j.actphy.2025.100109 shu

合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果

  • 1.

    澳门大学应用物理及材料工程研究院(IAPME), 教育部联合重点实验室, 氹仔 999078, 澳门特别行政区

  • 2.

    暨南大学化学与材料科学学院, 广东省超分子配位化学重点实验室, 广东 广州 510632

    • 通讯作者: 曲松楠, songnanqu@um.edu.mo
  • 基金项目:

    澳门特别行政区科学技术发展基金 0139/2022/A3

    澳门特别行政区科学技术发展基金 0002/2024/TFP

    澳门特别行政区科学技术发展基金 0007/2021/AKP

    澳门大学—何鸿燊博士医疗拓展基金会“扬帆起航·共创未来”2025年度资助 SHMDF-OIRFS/2025/001

    国家自然科学基金 62205384

  • †These authors contributed equally to this work
摘要: 碳点(CDs)因其优异的生物相容性和可调的光学特性，已成为近红外(NIR)介导的肿瘤治疗中极具前景的光热剂。然而，如何精确控制其组装行为以增强NIR吸收和光热转换效率仍不明确。在这项工作中，我们提出了一种因电子供体/受体复合而超组装的碳点(S-d/a-CDs)，通过将供电子碳点(d-CDs)与吸电子碳点(a-CDs)整合构建而成。这种复合的超碳点显著增强了S-d/a-CDs的NIR吸收能力。在740 nm激光照射下，S-d/a-CDs实现了65.8%的显著光热转换效率(PTCE)。S-d/a-CDs通过静脉注射表现出可忽略的细胞毒性和有效的肿瘤积累能力，能够在NIR激光照射后完全消除肿瘤。据我们所知，本研究首次利用两种CDs的协同组装进行光物理特性工程，为开发先进的NIR触发光热材料建立了开创性的范式。

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  • 发布日期:  2025-09-15
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