Citation: Jiaqiong Sun, Guangfan Zheng, Yongmei Fu, Qiao Zhang, Yimin Wang, Qian Zhang, Yan Li, Qian Zhang. Copper-catalyzed tandem radical amination/1, 2-carbon migration of allylic alcohols: Direct access to α-quaternary-β-amino ketones[J]. Chinese Journal of Catalysis, ;2018, 39(1): 138-145. doi: 10.1016/S1872-2067(17)62915-2 shu

Copper-catalyzed tandem radical amination/1, 2-carbon migration of allylic alcohols: Direct access to α-quaternary-β-amino ketones

Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, Jilin, China

Received Date: 4 September 2017
Revised Date: 15 September 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (21372041), Changbai Mountain Scholarship Program, and the Fundamental Research Funds for the Central Universities (2412016KJ006).

A novel nitrogen-centered radical-induced 1,2-carbon migration reaction of allylic alcohols has been developed. This method provides easy access to a variety of α-quaternary-β-amino ketones under mild reaction conditions. The reaction has a wide substrate scope and operational simplicity. Mechanistic studies suggest that 1,2-carbon migration is induced by regioselective nitrogen-centered radical addition to the alkene unit.
- Allylic alcohols,
- Nitrogen-centered radicals,
- 1,2-Carbon migration,
- α-Quaternary-β-amino ketones,
- N-F regent
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