Citation: Mehdi Rimaz, Farkhondeh Aali. An environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines[J]. Chinese Journal of Catalysis, ;2016, 37(4): 517-525. doi: 10.1016/S1872-2067(15)61060-9 shu

An environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines

Mehdi Rimaz ^, ,
Farkhondeh Aali

1.
Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran

Corresponding author: Mehdi Rimaz,
Received Date: 7 January 2016
Available Online: 29 January 2016

This report describes a new three-component strategy for the regioselective synthesis of a series of tri-substituted pyridazines via a 1,4-diazabicyclo[2.2.2]octane (DABCO)-catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one-pot route toward a diverse set of 3,6-diaryl-4-methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base-organocatalyst, and affords good to excellent yields of products.
- 1,4-Diazabicyclo[2.2.2]octane (DABCO),
- Propiophenone,
- Arylglyoxalmonohydrate,
- Pyridazine
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