Citation: Hossein Naeimi, Hossein Foroughi. Efficient, environmentally benign, one-pot procedure for the synthesis of 1, 5-benzodiazepine derivatives using N-methyl-2-pyrrolidonium hydrogen sulphate as an ionic liquid catalyst under solvent-free conditions[J]. Chinese Journal of Catalysis, ;2015, 36(5): 734-741. doi: 10.1016/S1872-2067(14)60304-1 shu

Efficient, environmentally benign, one-pot procedure for the synthesis of 1, 5-benzodiazepine derivatives using N-methyl-2-pyrrolidonium hydrogen sulphate as an ionic liquid catalyst under solvent-free conditions

Hossein Naeimi ^, ,
Hossein Foroughi

1.
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317, Iran

Corresponding author: Hossein Naeimi,
Received Date: 22 December 2014
Available Online: 23 January 2015

A powerful and environmentally benign method has been developed for the one-pot synthesis of 4-substituted-1,5-benzodiazepines via the three-component reaction of a series of aldehydes with dimedone and o-phenylenediamine using [H-NMP][HSO₄] as a Brönsted acidic ionic liquid catalyst under solvent-free conditions. The key benefits of this new method over existing techniques include high yields, the use of a green catalyst, short reaction times and facile catalyst separation.
- Ionic liquid,
- Benzodiazepine,
- Solvent-free conditions,
- Dimedone
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