Citation: Nader Ghaffari Khaligh. One-pot multicomponent synthesis of unsymmetrical polyhydroquinoline derivatives with 1,1’-butylenebispyridinium hydrogen sulfate as an efficient, halogen-free and reusable Brönsted ionic liquid catalyst[J]. Chinese Journal of Catalysis, ;2014, 35(9): 1497-1503. doi: 10.1016/S1872-2067(14)60087-5 shu

One-pot multicomponent synthesis of unsymmetrical polyhydroquinoline derivatives with 1,1’-butylenebispyridinium hydrogen sulfate as an efficient, halogen-free and reusable Brönsted ionic liquid catalyst

Nader Ghaffari Khaligh ^,

1.
Research House of Professor Reza, Education Guilan, Rasht, District 1, 41569-17139, Iran

Corresponding author: Nader Ghaffari Khaligh,
Received Date: 21 February 2014
Available Online: 21 March 2014

1,1'-Butylenebispyridinium hydrogen sulfate is an efficient, halogen-free and reusable Brönsted ionic liquid catalyst for the synthesis of ethyl-4-aryl/heteryl-hexahydro-trimehtyl-5- oxoquinoline-3-carboxylates by the one-pot condensation of dimedone, aryl/heteryl aldehydes, ethyl acetoacetate, and ammonium acetate under solvent-free conditions. This method has the advantages of high yield, clean reaction, simple methodology, and short reaction time. The ionic liquid can be recycled five times without significant loss of the catalytic activity.
- Unsymmetric polyhydroquinolines,
- Brönsted acidic ionic liquid,
- Ultrasonication,
- Multicomponent,
- Solvent-free
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