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Citation: Jianwei Wei, Wengang Guo, Boyu Zhang, Yan Liu, Xin Du, Can Li. An amphiphilic organic catalyst for the direct asymmetric Michael addition of cycloketone to nitroolefins in water[J]. Chinese Journal of Catalysis, ;2014, 35(7): 1008-1011. doi: 10.1016/S1872-2067(14)60080-2 shu

An amphiphilic organic catalyst for the direct asymmetric Michael addition of cycloketone to nitroolefins in water

Jianwei Wei ^a,b ,
Wengang Guo ^b ,
Boyu Zhang ^b ,
Yan Liu ^b,, ,
Xin Du ^a,, ,
Can Li ^b,,

1.
a. Department of Chemistry, Dalian University of Technology, Dalian 116024, Liaoning, China;

Corresponding author: Yan Liu, Xin Du, Can Li,
Received Date: 21 December 2013
Available Online: 11 March 2014
Fund Project:

A series of amphiphilic proline-derived mercapto imidazole organic catalysts were synthesized and shown to be very effective with an acid cocatalyst for the asymmetric Michael addition reaction of ketones to nitroolefins with high diastereoselectivity (up to 99:1) and execellent enantioselectivity (up to 96%) using water as solvent.
- Asymmetric catalysis,
- Emulsion,
- Organocatalysis,
- Michael addition
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