Citation: Nader Ghaffari Khaligh. Four-component one-pot synthesis of unsymmetrical polyhydroquinoline derivatives using 3-methyl-1-sulfonic acid imidazolium hydrogen sulfate as a catalyst[J]. Chinese Journal of Catalysis, ;2014, 35(7): 1036-1042. doi: 10.1016/S1872-2067(14)60038-3 shu

Four-component one-pot synthesis of unsymmetrical polyhydroquinoline derivatives using 3-methyl-1-sulfonic acid imidazolium hydrogen sulfate as a catalyst

Nader Ghaffari Khaligh ^a,b,,

1.
a. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, 47651-61964, Iran;

Corresponding author: Nader Ghaffari Khaligh,
Received Date: 12 December 2013
Available Online: 15 January 2014

3-Methyl-1-sulfonic acid imidazolium hydrogen sulfate has been used as an efficient, halogen-free, and reusable Brönsted acidic ionic liquid catalyst for the synthesis of ethyl-4-aryl/heteryl-hexahydro-trimehtyl-5-oxoquinoline-3-carboxylates via the one-pot condensation of dimedone with aryl/heteryl aldehydes, ethyl acetoacetate, and ammonium acetate under solvent-free conditions. This method has the advantage of being clean and simple, as well as providing the desired product in high yield over a short reaction time. Furthermore, the catalyst could be recycled and reused four times without any discernible reduction in activity.
- Unsymmetrical polyhydroquinoline,
- Brönsted acidic ionic liquid catalyst,
- Multicomponent reaction,
- Solvent-free condition
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