Citation: Si Zhang, Xi-Mian Xiao, Fan Qi, Peng-Cheng Ma, Wei-Wei Zhang, Cheng-Zhi Dai, Dan-Feng Zhang, Run-Hui Liu. Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes[J]. Chinese Journal of Polymer Science, ;2019, 37(11): 1105-1112. doi: 10.1007/s10118-019-2278-0 shu

Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes

State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Run-Hui Liu, rliu@ecust.edu.cn
Received Date: 13 March 2019
Revised Date: 13 April 2019
Accepted Date: 18 April 2019
Available Online: 17 June 2019

Gram-negative bacteria can cause serious infections and are well known problems in biomedical practices. Biofilms of gram-negative bacteria are notorious for their frequently encountered resistance toward antibiotics. We demonstrate that α/β chimeric polypeptide molecular brush (α/β CPMB) exerts potent activities against antibiotic-resistant gram-negative bacteria. MTT viability assay, bacterial colony counting, and live/dead staining all indicate that α/β CPMB not only inhibits biofilm formation of gram-negative Pseudomonas aeruginosa and Acinetobacter baumannii, but also effectively disrupts mature biofilms that are highly resistant to one of the most active antibiotics—colistin. The superior antibacterial performance of the α/β CPMB implies its potential topical applications in treating biofilms.
- Molecular brush,
- Chimeric polypeptide,
- Biofilm,
- Antimicrobial resistance,
- Host defense peptide
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