Citation: Juan Du, Ji-Hu Wang, Hai-Yan Yu, Yan-Yan Zhang, Li-Hui Pu, Jin-Cheng Wang, Shu-Yang Lu, Si-Hao Chen, Tong-He Zhu. Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction[J]. Chinese Journal of Polymer Science, ;2019, 37(6): 560-569. doi: 10.1007/s10118-019-2231-2 shu

Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction

Juan Du ¹ ,
Ji-Hu Wang ¹ ,
Hai-Yan Yu ¹ ,
Yan-Yan Zhang ¹ ,
Li-Hui Pu ¹ ,
Jin-Cheng Wang ¹ ,
Shu-Yang Lu ⁴ ,
Si-Hao Chen ^1,, ,
Tong-He Zhu ^2,3,,

a.
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
b.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
c.
Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
d.
Shanghai Institute of Cardiovascular Disease, Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Corresponding author: Si-Hao Chen, chensh@sues.edu.cn Tong-He Zhu, zhutonghe89@163.com
Received Date: 23 December 2018
Revised Date: 19 January 2019
Available Online: 27 February 2019

Electrospun nanofibrous mats represent a new generation of medical textiles with promising applications in heart valve tissue reconstruction. It is important for biomaterials to mimic the biological and mechanical microenvironment of native extracellular matrix (ECM). However, the major challenges are still remaining for current biomedical materials, including appropriate mechanical properties, biocompatibility, and hemocompatibility. In the present work, the novel composite nanofibrous mats of poly(p-dioxanone) (PDO) and poly(ester-urethane)ureas (PEUU) are fabricated by electrospinning system. The optimal combination ratio of PDO to PEUU may balance the mechanical properties and cellular compatibility to match the newly formed tissue. In PDO/PEUU composite nanofibrous mats, PEUU can provide the biomimetic elastomeric behavior, and PDO could endow the excellent biocompatibility. In comparison to nanofibrous mat of neat PDO, the composite showed significantly improved mechanical properties, with 5-fold higher initial elongation at break. Furthermore, human umbilical vein endothelial cells (HUVECs) were cultured on the composite to evaluate its ability to rapidly endothelialize as heart valve tissue engineering. The results revealed that PDO/PEUU composite nanofibrous mats could promote cell adhesion and proliferation, especially for the ratio of 60/40. Overall, PDO/PEUU composite nanofibrous mats (60/40) show the excellent mechanical properties, appropriate biocompatibility and hemocompatibility which meet the necessary norm for tissue engineering and may be suitable for potential heart valve tissue reconstruction.
- Poly(p-dioxanone),
- Poly(ester-urethane)ureas,
- Electrospinning,
- Composite nanofiber,
- Tissue engineering
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