Citation: Silvana Alfei, Gaby Brice Taptue, Silvia Catena, Angela Bisio. Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids[J]. Chinese Journal of Polymer Science, ;2018, 36(9): 999-1010. doi: 10.1007/s10118-018-2124-9 shu

Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

Dipartimento di Farmacia, Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Viale Cembrano 4, I-16148 Genova, Italy

Corresponding author: Silvana Alfei, alfei@difar.unige.it
Received Date: 15 December 2017
Revised Date: 15 December 2017
Accepted Date: 7 February 2018
Available Online: 28 March 2018

Dendrimers are macromolecules characterized by high controlled size, shape and architecture, presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications, including gene transfection, tissue engineering, imaging, and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility, non-specific cell distribution, low bioavailability, poor pharmacokinetics, and their direct administration could result in the release of thrombi. To overcome such problems, in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR, NMR, zeta potential, mean size of particles, buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold, thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.
- Polyester-based amino acids-modified dendrimers,
- Physical encapsulation,
- Water-soluble dendriplexes,
- Buffer capacity,
- NMR investigations
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