Citation: Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, Bao-Gang Wang. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, ;2018, 36(1): 18-24. doi: 10.1007/s10118-018-2008-z shu

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

a.
College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China
b.
Engineering Research Center of Oilfield Chemistry, Ministry of Education, Chengdu 610500, China

Corresponding author: Zhi-Yu Huang, hzy3019@163.com Hong-Sheng Lu, hshlu@swpu.edu.cn
Received Date: 25 April 2017
Revised Date: 5 July 2017
Accepted Date: 5 July 2017
Available Online: 20 October 2017

A series of triblock copolymers, containing a CO₂-switchable block poly(2-(dimethylamino)ethyl methacrylate) (PDM) block and two symmetrical hydrophilic blocks polyacrylamide (PAM), were synthesized using atom transfer radical polymerization (ATRP) method. The pH and conductivity tests showed that the triblock copolymer exhibited switchable responsiveness to CO₂, i.e. a relatively low conductivity of solution could be switched on and off by bubbling and removing of CO₂, and the triblock copolymer aqueous solution displayed a CO₂-switchable viscosity variation. The changes were all attributed to protonation of tertiary amine groups in PDM blocks and proven by ¹H-NMR. Cryogenic transmission electron microscopy and dynamic light scattering characterization demonstrated that the viscosity variation was the result of a unilamellar vesicle-network aggregate structure transition. The release of rhodamine B from the vesicles with and without CO₂ stimuli showed the potential application in drug delivery domains; after CO₂ bubbling, the drug release rate could be accelerated. Finally, reasonable mechanism of CO₂-switchable morphology changes and CO₂-induced drug release was proposed.
- ATRP,
- CO₂-sensitive,
- Polymeric vesicles,
- Drug release
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

CO2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

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通讯作者: 陈斌, bchen63@163.com

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle