Citation: Hao Su, Yuzhu Wang, Caleb F. Anderson, Jin Mo Koo, Han Wang, Honggang Cui. Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1194-1211. doi: 10.1007/s10118-017-1998-2 shu

Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators

Hao Su ^a,b ,
Yuzhu Wang ^a,b ,
Caleb F. Anderson ^a,b ,
Jin Mo Koo ^a,b ,
Han Wang ^a,b ,
Honggang Cui ^a,b,c,d,,

a.
Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
b.
Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
c.
Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
d.
Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA

Corresponding author: Honggang Cui, hcui6@jhu.edu
Received Date: 28 May 2017
Revised Date: 20 June 2017
Accepted Date: 21 June 2017

Fund Project: the National Science Foundation DMR 1255281

Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and π-π stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions.
- Peptide,
- Hydrogels,
- Peptide conjugates,
- Supramolecular nanostructures,
- Molecular assembly
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