Citation: Hao-yang Jia, Jie-zhong Shi, Yu Shao, Dong-sheng Liu. DNA Hydrogels Formed of Bended DNA Scaffolds and Properties Study[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1307-1314. doi: 10.1007/s10118-017-1978-6 shu

DNA Hydrogels Formed of Bended DNA Scaffolds and Properties Study

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: Dong-sheng Liu, liudongsheng@tsinghua.edu.cn
Received Date: 28 April 2017
Revised Date: 13 May 2017
Accepted Date: 17 May 2017

Fund Project: the National Basic Research Program of China 2013CB932803the National Basic Research Program of China 973 programthe National Natural Science Foundation of China 21534007

In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine (C)-rich sequence on both ends. This brick can first assemble to form duplex under pH 8 condition. After adjusting the pH to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.
- Linear DNA,
- Hydrogel,
- Bended structures
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