Citation: Hao-yang Jia, Jie-zhong Shi, Yu Shao, Dong-sheng Liu. DNA Hydrogels Formed of Bended DNA Scaffolds and Properties Study[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1307-1314. doi: 10.1007/s10118-017-1978-6 shu

DNA Hydrogels Formed of Bended DNA Scaffolds and Properties Study

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: Dong-sheng Liu, liudongsheng@tsinghua.edu.cn
Received Date: 28 April 2017
Revised Date: 13 May 2017
Accepted Date: 17 May 2017

Fund Project: the National Basic Research Program of China 2013CB932803the National Basic Research Program of China 973 programthe National Natural Science Foundation of China 21534007

In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine (C)-rich sequence on both ends. This brick can first assemble to form duplex under pH 8 condition. After adjusting the pH to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.
- Linear DNA,
- Hydrogel,
- Bended structures
1. [1]
  Seeman, N.C., Nature, 2003, 421:427 doi: 10.1038/nature01406
2. [2]
  Seeman, N.C., J. Theor. Biol., 1982, 99:237 doi: 10.1016/0022-5193(82)90002-9
3. [3]
  Rthemund, P.W.K., Nature, 2006, 440:297 doi: 10.1038/nature04586
4. [4]
  Yan, H., Park. S.H., Finkelstein, G., Reif, J.H. and Labean, T.H., Science, 2003, 301:1882 doi: 10.1126/science.1089389
5. [5]
  He, Y., Ye, T., Su, M., Zhang, C., Ribbe, A.E., Jiang, W. and Mao, C.D., Nature, 2008, 452:198 doi: 10.1038/nature06597
6. [6]
  Zhao, Z.Y., Chen, C., Dong, Y.C., Yang, Z.Q., Fan, Q.H. and Liu, D.S., Angew. Chem. Int. Ed., 2014, 53:13468 doi: 10.1002/anie.201408231
7. [7]
  Dong, Y.C., Sun, Y.W., Wang, L.Y., Wang, D.M., Zhou, T., Yang, Z.Q., Chen, Z., Wang, W.B., Fan, Q.H. and Liu, D.S., Angew. Chem. Int. Ed., 2014, 53:2607 doi: 10.1002/anie.201310715
8. [8]
  Liu, D.S., Cheng, E.J. and Yang, Z.Q., NPG Asia Mater., 2011, 3:109 doi: 10.1038/asiamat.2011.147
9. [9]
  Dong, Y.C., Yang, Z.Q. and Liu, D.S., Acc. Chem. Res., 2014, 47:1853 doi: 10.1021/ar500073a
10. [10]
  Shao, Y., Li, C., Zhou, X., Wu, F., Jia, H.Y., Wang, Y.J. and Liu, D.S., Polymer Bulletin (in Chinese), 2015, (10):100
11. [11]
  Roh, Y.H., Ruiz, R.C.H., Peng, S.M., Lee, J.B. and Luo, D., Chem. Soc. Rev., 2011, 40:5730 doi: 10.1039/c1cs15162b
12. [12]
  Watson, J.D. and Crick, F.H.C., Nature, 1953, 171:737 doi: 10.1038/171737a0
13. [13]
  Gehring, K., Leroy, J.L. and Gueron, M., Nature, 1993, 363:561 doi: 10.1038/363561a0
14. [14]
  Leroy, J.L., Gehring, K., Kettani, A. and Gueron, M., Biochemistry, 1993, 32:6019 doi: 10.1021/bi00074a013
15. [15]
  Chen, C., Li, M., Xing, Y.Z., Li, Y.M., Joedecke, C.C., Jin, J., Yang, Z.Q. and Liu, D.S., Langmuir, 2012, 28:17743 doi: 10.1021/la303851a
16. [16]
  Liu, D.S. and Balasubramanian, S., Angew. Chem. Int. Ed., 2003, 42:5734 doi: 10.1002/(ISSN)1521-3773
17. [17]
  Shu, W.M., Liu, D.S., Watari, M., Riener, C.K., Strunz, T., Welland, M.E., Balasubramanian, S. and Mckendry, R.A., J. Am. Chem. Soc., 2005, 127:17054 doi: 10.1021/ja0554514
18. [18]
  Liu, D.S., Bruckbauer, A., Abell, C., Balasubramanian, S., Kang, D.J., Klenerman, D. and Zhou, D.J., J. Am. Chem. Soc., 2006, 128:2067 doi: 10.1021/ja0568300
19. [19]
  Wang, S.T., Liu, H.J., Liu, D.S., Ma, X.Y., Fang, X.H. and Jiang, L., Angew. Chem. Int. Ed., 2007, 46:3915 doi: 10.1002/(ISSN)1521-3773
20. [20]
  Hou, X., Guo, W., Xia, F., Nie, F.Q., Dong, H., Tian, Y., Wen, L.P., Wang, L., Cao, L.X., Yang, Y., Xue, J.M., Song, Y.L., Wang, Y.G., Liu, D.S. and Jiang, L., J. Am. Chem. Soc., 2009, 131:7800 doi: 10.1021/ja901574c
21. [21]
  Shao, Y., Jia, H.Y., Cao, T.Y. and Liu, D.S., Acc. Chem. Res., 2017, 50:659 doi: 10.1021/acs.accounts.6b00524
22. [22]
  Cheng, E.J., Xing, Y.Z., Chen, P., Yang, Y., Sun, Y.W., Zhou, D.J., Xu, L.J., Fan, Q.H. and Liu, D.S., Angew. Chem. Int. Ed., 2009, 48:7660 doi: 10.1002/anie.v48:41
23. [23]
  Xing, Y.Z., Cheng, E.J., Yang, Y., Chen, P., Zhang, T., Sun, Y.W., Yang, Z.Q. and Liu, D.S., Adv. Mater., 2011, 23:1117 doi: 10.1002/adma.201003343
24. [24]
  Li, C., Jones, A.F., Dun, A.R., Jin, J., Chen, P., Xing, Y.Z., Yang, Z.Q., Li, Z.B., Shu, W.M., Liu, D.S. and Duncan, R.R., Angew. Chem. Int. Ed., 2015, 54:3957 doi: 10.1002/anie.201411383
25. [25]
  Jiang, H.L., Pan, V., Vivek, S., Weeks, E.R. and Ke, Y.G., Chem. Bio. Chem., 2016, 17:1156 doi: 10.1002/cbic.201500686
26. [26]
  Shi, J.Z., Jia, H.Y. and Liu, D.S., Acta Polymerica Sinica (in Chinese), 2017, (1):135
27. [27]
  Noll, T., Schonherr, H., Wesner, D., Schopferer, M., Paululat, T. and Noll, G., Angew. Chem. Int. Ed., 2014, 53:8328 doi: 10.1002/anie.v53.32
28. [28]
  Horvath, S.J., Firca, J.R., Hunkapiller, T., Hunkapiller, M.W. and Hood, L., Method. Enzymol., 1987, 154:314 doi: 10.1016/0076-6879(87)54082-4
29. [29]
  Winter, H.H. and Chambon, F., J. Rheol., 1986, 30:367 doi: 10.1122/1.549853
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